ESOMYEN-DSR.Esomeprazole and domperidone capsules are a combination medication used to treat gastrointestinal issues like acid reflux (GERD) by reducing stomach acid and increasing stomach and intestinal movement. Esomeprazole, a proton pump inhibitor, lowers stomach acid, while domperidone, a prokinetic, speeds up digestion to relieve symptoms such as heartburn, nausea, and stomach pain.