SKAYCLO-P tablets are used to relieve pain, inflammation, and fever associated with conditions like rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and musculoskeletal pain. They are also used for other types of pain, such as toothache, back pain, or pain in the ear and throat. The combination works by reducing inflammation and blocking pain signals, while paracetamol helps lower fever.